ELIQUIS (Apixaban) is a medication that may be prescribed for one of the following reasons:
- Treat deep vein thrombosis (DVT) or pulmonary embolism (PE) and to reduce the risk of it happening again
- Provide prophylaxis for DVT and PE in certain high-risk patients, like those undergoing knee or hip replacement surgery
- Reduce the risk of stroke in patients with nonvalvular atrial fibrillation
If a clot forms in the veins, it can break off and lead to harmful and sometimes deadly events like a cardiovascular accident (stroke), myocardial infarction (heart attack), or PE (clot in the lungs). Certain people are at high risk of clot formation, including those who have had a clot before and those with atrial fibrillation.
Atrial fibrillation is an irregular heart rhythm where one of the chambers of the heart “quivers” instead of efficiently pumping blood. This causes blood to stay in one spot and increases the risk of a clot.
ELIQUIS works by targeting a protein in the clotting cascade, called factor Xa (Ten A). Shutting off this protein slows down clot formation, preventing their formation.
The normal dose of ELIQUIS (apixaban) is 5 mg twice daily.
The dose may be decreased to 2.5 mg twice in certain patients based on characteristics like weight, age, and kidney function.
The active ingredient of ELIQUIS is apixaban.
ELIQUIS cannot be used by those with artificial heart valves.
Patients with triple phospholipid syndrome (a genetic clotting disorder) should not use ELIQUIS.
If you experience bleeding or bruising that does not stop while taking ELIQUIS, call your doctor.
Since ELIQUIS works by slowing the clotting cascade, the main side effects are related to bleeding. Examples of major bleeding events include:
- Blood in the urine or stool
- Gastrointestinal bleeding
- Hemorrhagic stroke
- Intracranial hemorrhage
Example of minor side effects related to bleeding include:
- Bleeding gums
- Cuts that take longer to heal
- Nose bleeds
Speak with your doctor for management strategies around bleeding side effects and for a full list.